Abstract
The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.
MeSH terms
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Area Under Curve
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Benzoxazines / chemistry*
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Benzoxazines / pharmacology
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Chemistry, Pharmaceutical / methods*
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Crystallography, X-Ray / methods
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Drug Design
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Humans
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Inflammation
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Inhibitory Concentration 50
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Models, Chemical
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Molecular Structure
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Oxazines / chemical synthesis*
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Oxazines / pharmacology*
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Phosphatidylinositol 3-Kinases / metabolism*
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Protein Isoforms
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Structure-Activity Relationship
Substances
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Benzoxazines
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Oxazines
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Protein Isoforms
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Phosphatidylinositol 3-Kinases